Caracterização da mucilagem de sementes de chia para potencial uso em oftalmologia

• Ano de defesa: 2017
• Autor(a) principal: Ragazzi, Raul Diniz [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Mucilage; Toxicity; Chia; Viscosity; Mucilagem; Toxicidade; Viscosidade
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5098821; http://repositorio.unifesp.br/handle/11600/50126

Having in view its viscosity, obtained from the mucilage, a very low toxicity and their physico-chemical characteristics, it was noticed that the use of possible vehicles for ophthalmological use of drugs could be taken into account, knowing that in ophthalmology, the use of viscous products - particularly topical - has great value at time of contact with the ocular surface. In this sense, the present study deals with the development of a method for characterization and analysis. Its use as a vehicle of oral medications is also widely known as bases for syrups and laxatives, due to the property to provide an indigestible residue, to increase fecal bulk and stimulate peristalsis The mucilage found in the seeds of chia it is a source of fatty acids, omega 3, antioxidants, proteins, vitamins, minerals and dietary fiber. When these dry seeds are added to water, a highly viscous solution is generated due to the release of mucilage and high molecular weight carbohydrates, with wide application in food industry and pharmaceuticals. This project was conceived on the basis of the characterization and analysis of extracted mucilage chia seed (Salvia hispanica L.). Toxicity tests, eye irritation and corrosion properties were assessed for the safety of the product, which also underwent an analysis for its characterization, demonstrating their structural and functional characteristics. In tests no toxicity, irritability or corrosion properties and its characterization and structural and functional characteristics was demonstrated. For the first time was evaluated chia seed for possible use in ophthalmology. The toxicity studies, irritability and corrosion properties as well as characterization of the product were consensus and consistent with the literature. It has been shown by the tests mentioned above that chia has great potential for use in ophthalmology.