Investigação detalhada da utilidade do teste de sobregarga hídrica em pacientes com glaucoma primário de ângulo aberto: análise prospectiva observacional

• Ano de defesa: 2019
• Autor(a) principal: Delgado, Ana Luiza Bassoli Scoralick [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Open-Angle Glaucoma; Intraocular Pressure / Physiology; Techniques Of Ophthalmic Diagnosis; Overload Test; Glaucoma De Ângulo Aberto; Pressão Intraocular/Fisiologia; Técnicas De Diagnóstico Oftalmológico; Ritmo Circadiano; Teste De Sobrecarga Hibrida
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8034534; https://repositorio.unifesp.br/handle/11600/59667

Goal:Investigate the variation parameters (fluctuation and peak) of intraocular pressure (IOP) of long-term and short-term IOP variation parameters, obtained by the water overload (TSH), and its relationship with functional stage and progression of glaucoma. Methods:A prospective observational study was conducted, divided into four arms, where consecutively included patients treated with primary glaucoma of long-term stable open angle (GPAA) and patients with disease progression newly documented. Individuals with other eye diseases other than previous glaucoma or antiglaucomatous (incisional) surgery. The main criteria for inclusion criteria were: ≥5 visual field tests (VF), ≥3 retinographs / stereophotographs of optical disc and ≥3 years of follow-up, without any changes in the regimen current doctor. Stable GPAA was defined as the absence of progression in the CV (both event analysis as well as trend analysis) and the absence of anatomical changes follow-up. The progression of glaucoma was defined based on criteria structural and / or functional previously described. The long-term parameters were calculated based on isolated IOP measurements for each visit. To assess the short-term IOP parameters, patients underwent TSH standardized. Throughout the four different arms of the study, it was investigated: (1) first the correlation between long-term parameters (peak, fluctuation and average), (2) the agreement between each parameter of long-term IOP with those obtained TSH, (3) the relationship between TSH values ​​and functional damage, in addition to TSH behavior in eyes with asymmetric glaucoma, and finally, (4) the association between IOP variation parameters (both TSH derivatives and long-term) with disease progression.