Efeito do exercício físico forçado sobre a arquitetura do sono em ratos com epilepsia do lobo temporal

• Ano de defesa: 2016
• Autor(a) principal: Lima, Cristiano de [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Epilepsy; Temporal lobe epilepsy; Physical exercise; Sleep and electrocorticogram; Epilepsia; Epilepsia do lobo temporal; Exercício físico; Sono e eletrocortigrama
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3629608; http://repositorio.unifesp.br/handle/11600/46762

Patients with epilepsy present sleep disturbances, which may adversely impact quality of life, which can in turn, facilitate the seizure occurrence. Evidences from human and animals studies have demonstrated that exercise can exert beneficial effects such as reduction of seizure susceptibility and improvement of quality of life of individuals with epilepsy. Exercise has been found beneficial for enhancing the quality of sleep in patients with neurological disorders. In this regard, analysis of sleep patterns induced by exercise could provide information about the mechanisms by which exercise can exert positive influence on epilepsy. To investigate the influence of an acute exercise session on sleep pattern in rats with temporal lobe epilepsy (TLE), in addition to serum levels total testosterone and corticosterone. Twenty male Wistar rats were randomly distributed into 4 groups: control (C); acute exercise (EX); epilepsy (E) and epilepsy acute exercise (EEX). Two sleep electrocorticography recordings were performed during the light phase [(baseline and Day 2 (after acute physical exercise session)]. The following sleep parameters were evaluated: wakefulness, slow wave sleep (SWS), rapid eye movement (REM) sleep and total sleep time (TST). After baseline recording, the exercise groups (EX and EEX) were submitted to exercise session on a motor-driven treadmill at 12 m/min for 30 min. Twelve hours later, the rats were submitted to the second sleep recording. At baseline it was observed a higher wakefulness and a lower TST, SWS and REM sleep of animals with epilepsy compared to rats treated with saline. After acute exercise it was observed an increase in TST, SWS and a decrease of wakefulness in EEX (+11.10%, +20.29% and -11.25%, respectively) and EX (+5.20%, +11.60% and - 8.12%, respectively) groups. These results suggest that acute exercise positively impacted on the sleep patterns of rats with TLE and the influence of exercise on sleep demonstratred to be an excellent non-drug alternative for this population, contributing to a regenerative sleep and consolidated. Key-words: epilepsy, temporal lobe epilepsy, physical exercise, sleep and electrocorticogram.