Desenvolvimento farmacotécnico e validação analítica de comprimidos revestidos gastrorresistentes a partir do extrato padronizado de Harpagophytum procumbens DC

• Ano de defesa: 2017
• Autor(a) principal: Lopes, Andrey Pereira [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo
• Palavras-chave em Português: Pedaliaceae; Harpagophytum procumbens DC; Devil's claw; Traditional herbal medicine; Gastro-resistant coated tablets; Garra-do-diabo; Produto tradicional fitoterápico; Comprimidos gastrorresistentes
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=5001733; https://repositorio.unifesp.br/handle/11600/50267

The project aimed to develop a traditional herbal medicine from the dry extract, standardized in harpagoside, from the secondary roots of the plant species Harpagophytum procumbens DC. (Pedaliaceae), popularly known as "devil's claw". The tablets were developed from the dry extract of Harpagophytum procumbens DC. and produced by direct compression. Subsequently, they were coated with the appropriate gastro-resistant dispersion. Accelerated and long-term stability studies have been performed to define the period of use and validity. Gastro-resistant coated tablets, obtained from the dried extract of Harpagophytum procumbens DC., were standardized in harpagoside, and the analytical methodology was validated.