Avaliação histopatológica de botões corneanos provenientes de falência de transplante penetrante

• Ano de defesa: 2009
• Autor(a) principal: Santos, Leonardo Noleto Negry [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Córnea; Transplante; Falência
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9124

Purpose: To evaluate the histopathological features of corneal graft failures over time. Methods: A single-centered, retrospective analysis was performed on corneal specimens diagnosed as corneal graft failure retrieved from The Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a 9-year period. The corneal buttons were divided in three different groups according to the time between the diagnosis of corneal graft failure and regraft. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin (H&E) and periodic acid Schiff (PAS). Five different histopathological findings were evaluated in each specimen. Results: Overall, the most common histopathological findings was endothelial decompensation (97.2%). Subepithelial pannus (38.9%), vessels in the corneal stroma (11.1%), and anterior synechiae (2.8%) were the other present findings. The inflammatory reaction was considered discrete in 83.3% of the cases. The only significant histopathologic finding correlated with time was the presence of vessels in the corneal stroma (p=0.0092). Conclusions: Corneal neovascularization, represented by the presence of vessels in the corneal stroma, was the only histopathological finding correlated with time. Because it is a know factor of poor prognosis, our findings strongly support that early regraft has higher chances of success.