Comparação dos efeitos de diferentes intensidades de exercício físico agudo sobre aspectos fisiológicos, metabólicos e imunológicos de indivíduos com lesão medular

• Ano de defesa: 2016
• Autor(a) principal: Alves, Eduardo da Silva [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: spinal cord injury; physical exercise; cardiorespiratory; lesão medular; exercício físico; cardiorrespiratório; citocinas
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4038268; http://repositorio.unifesp.br/handle/11600/47852

The aim of this study was to compare the effect of different intensities of acute exercise on physiological, metabolic and immune aspects in individuals with spinal cord injury (SCI). 9 basketball wheelchair players with SCI and 9 controls (C) performed three exercise sessions at different intensities: ventilatory threshold 1 (VT1), 15% below VT1 and 15% above the VT1 with duration of ~ 24 - 34 minutes. For the assessment of the cardiorespiratory response was analyzed heart rate (HR), oxygen consumption (VO2), pulmonary ventilation (VE) and oxygen pulse (OP). Blood samples were collected before, immediately and 30 minutes after each exercise session to evaluate glucose, insulin, lipid profile and pro- and antiinflammatory cytokines. The absolute values of VO2, VE, PO, but not FC, were significantly lower in SCI group compared with C group during the same relative intensity of acute exercise. However, with the exception of VO2, the SCI group showed proportional increase in physiological responses compared to group C, with increasing intensity of acute exercise. Thirty minutes after the exercise session, the TG and VLDL in the SCI group were increased compared to baseline (p = 0.017), which was not observed in group C (p> 0.017). In group C, 30 minutes after the exercise session to 15% above the VT1, we found lower levels of blood glucose compared to baseline (p = 0.012). In the present study, we found an increase in baseline IL2 (p <0.005) and smaller concentrations of IL10 (p <0.001) and IL4 (p <0.001) in the SCI group compared to group C. During the acute exercise intensity at VT1, C group had higher IL-6 concentrations immediately after the exercise session compared to baseline (p = 0.012). In addition we found higher IL1ra values after exercise session in group C when compared to the SCI group the intensity of LV1 (p = 0.007) and 15% above the VT1 (p = 0.037). We conclude that basketball wheelchair players with SCI had lower absolute physiological responses compared to C group during acute exercise in the same relative intensity, except for HR. However, the increments of these physiological responses during acute exercise same relative intensity were similar between groups, except for VO2. Regarding the metabolic variables, only few changes were found in the lipid profile and glucose at different intensities of acute physical exercise, and these changes do not follow a pattern between the groups. Finally, as we hypothesize exercise conducted by the C group promotes greater impact on the plasma concentrations of IL6 reflecting an anti - inflammatory evident in group C compared to the SCI group.