Avaliação da neoplasia epitelial maligna do ovário recorrente através de PET-CT não dedicado 18F-FDG

• Ano de defesa: 2010
• Autor(a) principal: Sevillano, Marta Maite [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: PET-CT não dedicado; Neoplasia ovariana recorrente; Cintilografia; Neoplasias ovarianas; Ovarian cancer; Recurrent; Non-dedicated PET-CT
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9028

Purpose The aim of this study was to compare the impact of the survival in patients with ovarian cancer recurrence undergoing non-dedicated [18F]FDG PET-CT, CT and serum CA-125 (group A) and patients that were submitted to conventional follow-up with CT and serum CA-125. Methods Patients diagnosed with epithelial ovarian cancer at the AC Camargo Cancer Hospital from January 1996 to December 2003 who presented recurrence (checked by surgery), and performed [18F]FDG PET-CT on a total of 44 patients- group A, and 31 patients -group B undergoing conventional follow up. Patients undergoing chemotherapy less than 48 hours before non-dedicated PET-CT were excluded from the research. Results Patients of Group A presented an increase on their survival rate of 5.94 in comparison with group B (p=0.0200). The 11 borderline patients in group A performed 29 [18F]FDG PET-CT studies with 1 false negative (peritoneal implants), 10 true negatives and 18 true positives. Conclusion Oncologists are used to test several markers in order to perform diagnosis, staging and prognosis, but their real benefit in the treatment is still uncertain. The use of [18F]FDG PET-CT in the evaluation of subclinical ovarian cancer recurrence has been shown to be accurate and presented a rewarding cost-benefit relationship, interfering in the surgeons conduct facing a subclinical recurrence.