Hormonal and metabolic responses on overtraining syndrome (eros) - the eros study

• Ano de defesa: 2018
• Autor(a) principal: Cadegiani, Flavio Adsuara [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Adrenal; Sports endocrinology; Overtraining syndrome; Hormones; Endocrinologia esportiva; Síndrome do excesso de treinamento; Hormonios
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=6305270; https://repositorio.unifesp.br/handle/11600/52231

Purposes: Overtraining syndrome (OTS) is a disorder resulted from the combination of excessive training load and lack of adequate resting, which lead to a decrease in sport-specific performance and fatigue. There is a lack of knowledge about its pathophysiology and etiology of OTS. We designed the EROS study to evaluate the endocrine and metabolic responses in OTS, and addressed most of the challenging issues that limit the establishment of an adequate study methodology for OTS. Methods: We used multiple-step selection criteria, including several clinical and biochemical evaluations, to increase the accuracy of sample selection for the overtraining syndrome (OTS), healthy athlete (ATL) and healthy non-physically active (NCS) groups. The subjects underwent multiple rounds of interviews and biochemical and stimulation tests for the EROS-HPA axis, EROS-STRESS, EROS-BASAL and EROS-PROFILE arms of the EROS study. Results: A total of 51 subjects were selected (34.2% of the 146 initially recruited subjects). The baseline characteristics of the groups were similar, with the exception of body fat percentage, which was slightly lower in the ATL group. Conclusion: To the best of our knowledge, this is the most comprehensive study on OTS, and is the first to compare OTS subjects with physically active and also nonactive healthy subjects, and to perform gold-standard and exercise-independent tests, with multiple novel findings. Practical applications: The results of the EROS study will likely help improve the approach to the athlete, by providing useful information in regards to prevention, early identification and real underlying mechanisms of OTS.