Composição corporal e lipodistrofia em crianças e adolescentes pré-púberes infectados pelo HIV

• Ano de defesa: 2010
• Autor(a) principal: Palchetti, Cecília Zanin [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Composição corporal; Lipodistrofia; Nutrição; Criança; HIV
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9232

Objective: This study aims to compare BIA equations developed for healthy pediatric population and for HIV-infected children, using DXA as golden standard. Methods: Prospective transversal study including 40 prepubertal children and adolescents attended at the Pediatric Infectious Disease Clinic - Universidade Federal de São Paulo, São Paulo city, Brazil, from August to December, 2008. Epidemiological parameters (age,sex, HIV transmission), clinical and immunological status (CDC, 1994) and HAART were recorded. Body Mass Index (BMI) z-score and height-for-age z score were calculated to characterize the nutritional status and short stature (WHO, 2007). Body composition was analyzed by BIA and DXA. BIA equations for healthy pediatric population (Houtkooper et al.,1992) and for HIV-infected children (Arpadi et al. ,1996 and Joffe et al.,2005) were used. Data were analyzed using SPSS 12.0 software. Results: The mean age and standard deviation was 9,8 ±1,2 years, 50% were girls and 82,5% children from B e C categories. Total body fat mass, in kilograms and percentage, showed homogeneity between BIA and DXA values. However, there was no concordance regarding to fat free mass. The equation of Houtkooper et al. had good sensitivity and specificity while the equation developed by Joffe et al. had higher sensitivity, when comparing the percentage of total body fat mass measured by DXA. Conclusion: BIA has reliable data on total body fat mass. It is necessary to associate other methods to determine fat free mass because DXA shows limitations in routine use.