Metabolismo glicídico e adipocinas em trabalhadores em turnos fixos

• Ano de defesa: 2010
• Autor(a) principal: Padilha, Heloisa Vidigal Guarita [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Adipocinas; Cortisol; Trabalho em turnos; Metabolismo glicídico; Hidrocortisona; Metabolismo
• Link de acesso: http://repositorio.unifesp.br/handle/11600/9815

Introduction: Shift work has been associated with a higher propensity for the development of obesity, lack of food intake, insulin resistance and diabetes. Circulating levels of adiponectin, interleukin 6 and tumor necrosis factor-alpha also show involvement in glucose metabolism, Objective: The aim of the study was to investigate concentrations glucose metabolism and the adipokines levels among fixed shiftworkers. Materials and methods: The study included 22 fixed shiftworkers, aged between 20 and 35 years, male, Brasmetal steel industry, located in Diadema, São Paulo. There were three different shifts: night workers (n = 9), fixed early morning workers (n = 6), and dayworkers (n = 7). Blood samples were collected every 4 h over the course of 24 h, yielding 6 samples. Results: Total carbohydrate intake was lowest (p < 0.0005), while fat (p = 0.03) and protein (p < 0.0005) was highest on the early morning shifts comparing to dayworkers. The early morning workers also had overall elevated cortisol levels relative to the other two groups (p<0,05). Cortisol levels appeared to be more influenced by time since waking prior to the shift than by time-of-day. The early morning and night groups showed higher levels of HOMA-IR, which is a situation of insulin resistance. It was found an effect from shift on adiponectin and TNF-alpha, where the early morning workers were significant different from the dayworkers. There were no differences on IL-6 concentrations. Conclusion: the early morning group had the highest overall concentrations of cortisol and tended to have larger levels of HOMA-RI, indicating that more attention should be given to these workers. Moreover, all three groups showed pronounced cortisol levels on awakening, suggesting that they may have adjusted to their awaking time.