Tradução, adaptação cultural e validação para a Língua Portuguesa do Brasil do questionário Narcolepsy Severity Scale e avaliação dos fatores clínicos e laboratoriais associados a maior gravidade em uma população com narcolepsia tipo 1

• Ano de defesa: 2020
• Autor(a) principal: Pimentel Filho, Lúcio Huebra [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Narcolepsy; Symptom assessment; Translation; Validation study; Questionnaire; Narcolepsia; Avaliação de sintomas; Tradução; Estudo de validação; Questionário
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.xhtml?popup=true&id_trabalho=9106452; https://repositorio.unifesp.br/handle/11600/58763

Introduction: Narcolepsy type 1 is a sleep disorder that is a common cause of hypersomnia of central origin. It is characterized by sleep attacks, cataplexy, sleep-related hallucinations, sleep paralysis and sleep fragmentation in a pleomorphic presentation. In view of the complexity of determining its clinical severity, the Narcolepsy Severity Scale (NSS) was created, which is a questionnaire that assesses the frequency and impact of the main symptoms of narcolepsy. Methods: The Brazilian version of the NSS was developed following the steps: translation, back-translation, consensus and adaptation, pilot test with evaluation of doubts and suggestions, thus final consensus. The scale was applied to consecutive patients with an established diagnosis of narcolepsy type 1 at the daytime sleepiness service of the Psychobiology Department of the Universidade Federal de São Paulo (UNIFESP) between February 2018 and July 2019. They were evaluated with the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (ISPQ), in addition to clinical examination, demographic data and medical records. Patients on stable doses of medication were reevaluated after a period of 7 days and patients whose treatment was modified were reevaluated after 30 days. Results: A total of 52 patients completed the questionnaire. Small cultural adaptations were made to a better comprehension of Brazilian patients. The Brazilian version of the scale showed high internal consistency, demonstrated by the Cronbach's alpha coefficient of 0.82. It showed good reproducibility capacity, verified through the test-retest, whose intraclass correlation was 0.98. The average severity of Brazilian patients was 33.94 (± 11.24), higher than the values found in the French and Chinese population, which also underwent validation of this scale. There was a correlation between sleep latency in diagnostic polysomnography and the NSS severity scale. Conclusion: The Brazilian Portuguese version of the NSS is a valid and reproducible tool for assessing the severity of patients with type 1 narcolepsy.