Diferenças relacionadas ao gênero entre ratos submetidos a estímulo nociceptivo, associado ou não à analgesia na primeira semana de vida sobre o comportamento de ansiedade e memória espacial

• Ano de defesa: 2016
• Autor(a) principal: Rêgo, Débora da Silva Bandeira [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Pain; Neonatal; Rats; Behavior; Anxiety; Dor; Neonato; Ratos; Comportamento; Ansiedade
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3782222; http://repositorio.unifesp.br/handle/11600/47499

Analgesia by opioids has been widely used in neonatal intensive care units, although studies in premature infants and in animal models have been showed that the administration of this pharmacologic agent may produce physiological and behavior changes in short and long term. This study was conducted to evaluate the effect of an inflammatory nociceptive stimulus, characterized by the subcutaneous injection of Freund?s Complete Adjuvant in the left paw of male and female Wistar rats, on the first day of life, associated or not to analgesia by the subcutaneous injection of fentanyl from the first to the eighth day of life on: anxiety, assessed in the open field and elevated plus maze tests, and learning and spatial memory, examined in the Morris water maze test, in rats from seventy-fifth day of life. In the open field test, the females showed an anxious behavior as they spent more time in outer zone of maze when compared to males. In the elevated plus maze test, the animals that received the nociceptive stimulus associated to analgesia with fentanyl showed an anxiety behavior more evident when compared to control animals, as they spent less time in the open arms. The nociceptive stimulation alone or associated to analgesia did not affect learning in adulthood. Based in our data suggest that use of fentanyl for treatment of pain in neonates animals does not associate with later cognitive injury. However, the paradoxal effect of greater anxiety in animals treated with fentanyl in comparison to not treated, is surprising and deserve to be studied.