A estrutura e o metabolismo cerebral de crianças e adolescentes de 7 a 12 anos vítimas de violência

• Ano de defesa: 2017
• Autor(a) principal: Milani, Ana Carolina Coelho [UNIFESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Posttraumatic stress disorder; Children; MRI; Morphometry; Brain metabolism; Child abuse; Transtorno do estresse pós-traumático; Crianças; Ressonância magnética; Morfometria; Metabolismo cerebral; Maus-tratos infantis
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=4998105; http://repositorio.unifesp.br/handle/11600/50093

Child maltreatment is a global problem with serious consequences throughout life. Child abuse victims experience many, often multiple, adverse experiences that may result in behavioral changes and psychopathologies such as posttraumatic stress disorder. The main objective of the thesis is to evaluate the impact of traumatic experiences on children between 7 and 12 years of age, victims of violence (with or without psychiatric diagnosis - PTSD or PTSS), on the structure and brain metabolism using magnetic resonance imaging in a prospective study. As a methodology, the study was performed longitudinally (one year follow-up) in children aged 7 to 12 years, victims of violence (with PTSD or PTSS), and compared them with controls exposed to violence (but without psychopathology) and with healthy controls in relation to brain structure and metabolism (in the region of the anterior cingulate gyrus) through magnetic resonance imaging. The results suggest that although structural abnormalities were not observed in patients diagnosed with PTSS / PTSS, metabolic changes (NAA / Cr ratio) were already present, which might reflect that structural magnetic resonance imaging may not be sensitive enough to Detect subtle or shorttime changes, unlike spectroscopy. New longitudinal studies with larger populations and for a longer time are necessary to elucidate the psychobiological consequences of traumas in childhood and adolescence.