Avaliação in vitro da atividade de agentes antimicrobianos sintéticos e naturais frente à candida dubliniensis sensíveis e resistentes ao fluconazol

• Ano de defesa: 2013
• Autor(a) principal: Reginato, Cássia Franco Della Mea
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Odontologia; UFSM; Programa de Pós-Graduação em Ciências Odontológicas
• Palavras-chave em Português: Antissépticos; Suscetibilidade; Candida; Antiseptics; Susceptibility; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/6120

The susceptibilities of C.dubliniensis fluconazol-resistant (FR), C. dublinienis fluconazole-susceptible (FS) and C. albicans from oral candidiasis were tested to antiseptics chlorhexidine gluconate (CHX), cetylpiridinium chloride (CPC), triclosan (TCS) and natural compounds carvacrol, eugenol and thymol. In general C. dubliniensis FS was more sensitive to antiseptics than C. dublinienis FR and C. albicans. However to CHX the group FR was significantly less susceptible than the others. To fungicidal activity, the three groups did not show susceptibilities differences to CHX and TCS and the group FR was as sensitive as C. albicans to CPC. In general a similar profile of susceptibility was observed to natural products. The susceptibilities of the three groups of Candida spp to antiseptics confirmed the good antifungal activity of them. The authors discuss the importance of monitoring the susceptibility of Candida to antifungal agents as well as to antiseptics widely used in order to detect emergence of antiseptics resistance.