Sintese e avaliação como fotossensibilizadores de novos triazoil-fulerenos funcionalizados com AZT e com calcogenos derivados de AZT

• Ano de defesa: 2014
• Autor(a) principal: Ravanello, Bruno Brisólla
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Química; UFSM; Programa de Pós-Graduação em Química
• Palavras-chave em Português: Fulereno; Terapia fotodinâmica; Fotossensibilizador; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/10588

Herein we report the synthesis of a new class of AZT-functionalized fullerenes. The synthetic strategic furnished the desired products in few reactional steps, in a convergent manner, in yields ranging from 22 to 43 %. Studies of reaction conditions were also performed. Time, temperature, catalyst adding and solvents, involved in the main step of the synthesis were optimized. The target molecules were evaluated as photosensitizers for use in photodynamic therapy. The generation of singlet oxigen were confirmed using the singlet oxigen scavenger DPBF (1,3-diphenylisobenzofuran). Analysing the decay of the absorbance of DPBF at 418 nm, it was possible to measure the generation of singlet oxygen (1O2). In this context, the respective compounds showed a potential ability of 1O2 generation, demonstrating a prominent application of these molecules as photosensitizer