Parâmetros de estresse oxidativo em cães naturalmente infectados pelo vírus da cinomose

• Ano de defesa: 2013
• Autor(a) principal: Curtis, Andressa Oliveira de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Medicina Veterinária; UFSM; Programa de Pós-Graduação em Medicina Veterinária
• Palavras-chave em Português: Morbillivirus; Peroxidação lipídica; TBARS; Catalase; CAT; Superóxido dismutase; SOD; Lipid peroxidation; Superoxidedismutase; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/10148

Canine distemper disease is a severe multisystem disease that affects the respiratory, hemolymphatic, gastrointestinal and neurological systems. The lesions induced by replication of canine distemper virus (CDV) produce an increase in reactive oxygen species (ROS), leading to oxidative stress. The aim of this study was to investigate parameters of oxidative stress by measuring the lipid peroxidation through the thiobarbituric acid reactive substances (TBARS) and the activity of the enzymes catalase (CAT) and superoxide dismutase (SOD) in dogs naturally infected with distemper virus. In this study we used 33 animals positive for CDV, attended at the Veterinary Hospital of the University of Rio Grande do Sul (UFRGS) and 21 clinically healthy animals were used as control. For the confirmation of the diagnosis RT-PCR (Reverse Transcription Polymerase Chain Reaction) was performed in samples of rectal swab and/or serum. This study demonstrated a significant difference in lipid peroxidation, SOD and CAT activities in the analyzed groups, suggesting the involvement of oxidative stress in the pathogenesis of the disease.