Estudo dos constituintes quimicos isolados de plantas medicinais da região do vale do Purus no Acre (Amazônia)

• Ano de defesa: 2003
• Autor(a) principal: Graebner, Ilmar Bernardo
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Química; UFSM; Programa de Pós-Graduação em Química
• Palavras-chave em Português: Química farmcêutica; Amazônia; Plantas medicinais; Produtos naturais; Síntese orgânica; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/4153

The present work describes especially the extraction, isolation and identification of the chemical compounds of the tuber of Humirianthera ampla Miers (Icacynaceae) and the barks of the Himatanthus sucuuba Spruce (Apocynaceae). From the tuber of H. ampla, the diterpenes Humirianthol (3,18:14,16- diepoxi-3,15-dihydroxi-7-pimaren-17,6β-olida) (18) and acrenol (15,16-diol-3β,20- epoxi-3α-hydroxi-9-epi-7-pimaren-19,6β-olida) (19), isolated and identificated in the master studies, have your stereogenic centers definites at X ray technique and, at Horeau method. Though were isolated and identificated β-amyrin (37), sitosterol glycoside (45), plumeride (32) and glicoplumeric acid (1β-O-DGlicopyranosilpluméric) (33). From the barks of the H. sucuuba Wood were isolated one mixture the α-amyrin cinamate and α-lupeol cinamate, and allamandine-A (43), plumericin (44), and plumericin at to plumeride glycoside (32). The structures of the isolated compounds were established by spectral analysis (1H RMN, 13C RMN, COSY, DEPT 135O, DEPT 90O, HMQC, HMBC e NOESY), Infrared, X ray and comparisons among closely related compounds. Acetate derivatization from the diterpenes humirianthol and acrenol exhibited antifungic activity against Candida albicans and Sacharomyces cerivisae. The cloroformic fraction from the barks of the Himatanthus sucuuba exhibits activity against Staphylococcus aureus, S. epidermidis , Micrococcus luteus, Klebsiella pneumoniae, Escherichia coli and Salmonella setubal and antifungic activity against Candida albicans e Sacharomyces cerivisae. The allamandin A (43) and plumericin (44) exhibited activity equal to the cloroformic fraction.