Síntese, análise estrutural e avaliação mimética da atividade catalítica da superóxido dismutase de complexos de cobre derivados de hidrazidas aromáticas

• Ano de defesa: 2018
• Autor(a) principal: Siqueira, Josiéli Demetrio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; Brasil; Química; UFSM; Programa de Pós-Graduação em Química; Centro de Ciências Naturais e Exatas
• Palavras-chave em Português: Complexo de cobre; Piridoxal; Superóxido dismutase; Copper complex; Pyridoxal; Superoxide dismutase; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://repositorio.ufsm.br/handle/1/15931

This work presents the synthesis, characterization of copper (II) complexes and the potential of these compounds to mimic the catalytic activity of the enzyme superoxide dismutase. The complexes were obtained from the aldol condensation between substituted aromatic hydrazides and aromatic aldehydes (salicylic aldehyde and pyridoxal hydrochloride), resulting in eleven new copper (II) complexes. The complexes were structurally characterized by X-ray diffraction, cyclic voltammetry and complementary analysis. Subsequently, the compounds were evaluated for their antioxidant activities, using the NBT (Nitro blue tetrazolium chloride) photoreduction methodology. The results obtained for complexes derived from benzoic 4-amino hydrazide and benzoic 4- methoxy hydrazide with pyridoxal were considered promising for in vivo testing.