Avaliação de biomarcadores associados à inflamação e ao estresse oxidativo em pacientes com câncer de próstata

• Ano de defesa: 2013
• Autor(a) principal: Silveira, Rafael Arrua da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Farmacologia; UFSM; Programa de Pós-Graduação em Ciências Farmacêuticas
• Palavras-chave em Português: Câncer de próstata; Estresse oxidativo; Inflamação; Proteína C-reativa; C-reactive protein; Inflammation; Oxidative stress; Prostate cancer; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/6007

Changes in recent decades in morbidity and mortality of prostate cancer (CAP) is making if a public health problem in several countries, including Brazil. Several studies provide evidence that inflammatory processes and oxidative stress are considered important mechanisms involved in the pathogenesis and progression of CAP, as they induce aberrant cell growth, proliferation and neoplastic transformation of cells. Considering the interaction of these different mechanisms to the CAP, the objective of this study was to evaluate the levels of C-reactive protein (CRP), considered a biomarker of inflammation, as well as the assessment of ischemia modified albumin (IMA) and the ability reduction of iron in plasma (FRAP), novel biomarkers of oxidative stress in patients with CAP. This study included 30 healthy subjects and 25 patients with CAP, which had measured CRP levels, IMA, FRAP, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, creatinine, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), adenosine deaminase (ADA), prostate specific antigen total (tPSA), free prostate specific antigen (fPSA) and fraction of free PSA (fPSA%). The concentrations of tPSA, PCR and IMA were significantly higher in patients with CAP, whereas the concentrations of FRAP and fPSA%, were significantly lower in these same patients. It was also possible to observe significant correlations between% fPSA and CRP (r = -0.5059, P <0.001) and tPSA and CRP (r = 0.5104, P <0.001). These results suggest that oxidative and inflammatory processes are increased in prostate cancer, and there is a reduction in the antioxidant defenses in this pathology.