Polimorfismo do gene SPi2 na obstrução recorrente das vias aéreas e na doença inflamatória das vias aéreas em cavalos puro sangue de corrida

• Ano de defesa: 2008
• Autor(a) principal: Silva, Aline Correa da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Santa Maria; BR; Medicina Veterinária; UFSM; Programa de Pós-Graduação em Medicina Veterinária
• Palavras-chave em Português: Cavalo; Doença respiratória; SSCP; Alfa-1-antitripsina; Serpina; Horse; Respiratory disease; Alpha-1-antitrypsin; Serpine; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
• Link de acesso: http://repositorio.ufsm.br/handle/1/10026

Recurrent airway obstruction (RAO) and inflammatory airway disease (IAD) show high prevalence and are economically important in equine athletes. RAO is considered a multifactorial disease due to genetic and environmental components in their patophysiology. The aim of this study was to determine the presence of polymorphism at exons 2, 3, 4 and 5 of the SPi2 gene and a possible association between them and ORA or IAD on 51 thoroughbred horses through single-strand conformational polymorphism (SSCP). Exons 2, 3 and 4 of the Spi2 gene showed no polymorphism. On exon 5, 3 alleles and 6 genotypes were identified. Frequency of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO but no association was found between any polymorphism and horses with RAO or IAD.