Perfil laboratorial sérico e biliar em portadores de litíase da vesícula biliar

• Ano de defesa: 2005
• Autor(a) principal: Taqueda, Maria Stela Melo Santos
• Orientador(a): Alves Júnior, Antônio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• País: BR
• Palavras-chave em Português: litíase biliar; Colelitíase; Pólipo de vesícula; Colecistectomia
• Palavras-chave em Inglês: Biliary lithia sis; Cholelithiasis; Polip biliary; Cholecystectomy
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://ri.ufs.br/handle/riufs/3850

Biliary lithiasis is a metabolic disease that many risk factors participate of the etiopathogeny, and potentialize an eventual genetic condition. Prevalence in the western countries is about 10-15% of adults, being an important public health trouble. There is no knowledge about its pathogenesis yet, that can be associated to an unusual metabolism of cholesterol and lipoproteins. This study had aims to verify the relationship between serum and biliary levels of protein, cholesterol and calcium in patients with gallstones and gallbladder polip; identify if there is difference between laboratorial serum and biliary concentration of this elements in these two groups; study laboratorial serum and biliary profile in gallstones patients through of protein, cholesterol and calcium levels. This transversal study had two groups: a 41 gallstones patients and a 15 gallbladder polip patients as control group. Everyone was submitted to a videolaparoscopic cholecystectomy, when they had been taken blood and bile samples to be analyzed. In the blood was measured cholesterol total, LDL, HDL fractions, triglycerides, calcium total and protein total. In the bile was measured cholesterol total, calcium total and proteins. Statistical analysis was composed by use of F - test to normal distribution, Levene test to abnormal distribution. Student s t - test to medias comparison, analysis of variance of factor and Pearson correlation test p<0,05 was considered significant. It was found a stronger correlation between three elements measured in gallstone group. In polip group was found a strong correlation between calcium and protein biliary. There is no correlation between serum and biliary elements in gallstone group: calcium, cholesterol, LDL, HDL. Polip group had correlation between biliary protein and LDL serum, calcium biliary and HDL serum.With exception of protein and calcium biliary, more elevated in polip patients, every elements had statistics medias equals. Conclusions: there was no correlation between lipids elements bilia ries and serum in both studied groups; the medias of biliary and serum contents were statistically the same, with exception of protein and calcium biliary, had more elevated levels in polip group. The profile of serum and biliary elements was similar in both groups except for the biliary protein and of the triglycerids that presents some difference.