Efeitos do treinamento resistido de baixa intensidade na resposta nociceptiva e motora em modelo animal de dor crônica muscular difusa

• Ano de defesa: 2021
• Autor(a) principal: Santos, André Luiz Silva
• Orientador(a): Santana, Josimari Melo de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências Fisiológicas
• Palavras-chave em Português: Fibromialgia; Dor crônica; Hiperalgesia; Exercícios físicos; Atividade física; Treinamento de resistência; Ciências fisiológicas; Resistance training
• Palavras-chave em Inglês: Fibromyalgia; Chronic pain; Hyperalgesia; Physical activity
• Área do conhecimento CNPq: CIENCIAS BIOLOGICAS::FISIOLOGIA
• Link de acesso: https://ri.ufs.br/jspui/handle/riufs/14975

Fibromyalgia (FM) is characterized by different factors, such as chronic musculoskeletal pain, dysregulation of cardiac autonomic control and imbalance of inflammatory biomarkers. Such conditions are associated with increased fatigue and reduced functional capacity. Pharmacotherapy is commonly recommended, especially tricyclic antidepressants, however, they can cause adverse effects such as xerostomia, sedation and tachycardia. Thus, as a nonpharmacological treatment for FM, resistance training (RT) has been widely recommended. However, the effect of this training method on the animal model that mimics FM is not yet clear in the literature. Thus, the aim of the present study was to evaluate the effects of RT on the animal model of diffuse chronic muscle pain (DCMP). For this, 24 male Wistar rats were allocated into four groups: resistance training (RT), RT control, amitriptyline (AMITRIP) and AMITRIP control, all treatment protocols lasted 4 weeks. DCMP was induced in all animals by a double injection of acidic saline (pH 4.0) into the left gastrocnemius muscle. Sensory mechanical threshold, motor activity, were evaluated before and after induction of DCMP model and, before treatment, every week and at the end. Motor coordination was assessed once a week and muscle strength of hind limbs were also evaluated every two weeks. Animals treated with either TR or AMITRIP increased the mechanical withdrawal threshold (p <0.05) in relation to their controls, suggesting a reduction in mechanical hyperalgesia. However, it was not possible to observe improvement in motor displacement and motor coordination (p>0.05). However, animals with DCMP who underwent RT were able to increase the muscular strength of the hind limbs (p<0.0001) compared to the control group of the RT. These results suggest that RT promotes antihyperalgesic effects and improves muscle strength, but not functional capacity in an animal model of diffuse chronic muscle pain.