Detecção de tromboembolismo venoso e de níveis elevados de Dímero D em pacientes infectados pelos vírus Zika e Chikungunya

• Ano de defesa: 2019
• Autor(a) principal: Alves, Juliana Cardoso
• Orientador(a): Almeida, Roque Pacheco de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• Palavras-chave em Português: Zika vírus; Vírus Chikungunya; Tromboembolia Venosa
• Palavras-chave em Inglês: Chikungunya virus; Venous thromboembolism (VTE)
• Link de acesso: http://ri.ufs.br/jspui/handle/riufs/13056

Introduction: Arboviruses are diseases of viral etiology transmitted to hosts through hematophagous arthropods. Of great importance, the viruses infection Zika (ZIKV) and Chikungunya (CHIKV) may be asymptomatic or present with symptoms that range from mild to severe neurological disorders, such as Guillain-Barré Syndrome and Congenital Syndrome of the Zika virus. There is also cases reports describing coagulation disorders. To date, the vascular involvement triggered by the infections caused by ZIKV and CHIKV is poorly described. Objective: To describe 2 cases of deep venous thrombosis (DVT) associated with ZIKV and to evaluate serum D-dimer levels in patients infected with ZIKV and CHIKV virus. Methodology: This is a descriptive study, where 2 cases of DVT associated with ZIKV were reported, one from the University Hospital of Sergipe and the other from the University Hospital of Paraíba. In addition, plasma samples from 172 individuals infected by ZIKV (31) and CHIKV (141) were used, from the services offered by the University Hospital of the Federal University of Sergipe, from which clinical-epidemiological information was collected through a questionnaire, molecular diagnosis using real-time reverse transcription polymerase chain reaction (RT-PCR) and D-dimer dosing by enzyme-linked immunosorbent assay (ELISA). Results: Individuals infected with ZIKV and CHIKV had a mean age of 37.5 ± 13.35 years and 41.8 ± 17.3, respectively. The most affected gender was male (64%) by ZIKV and female (86.8%) by CHIKV. D-dimer levels were increased in 19.35% of the 31 ZIKV-positive individuals and in 63.83% of the 141 CHIKV-positive individuals. Conclusion: This study describes for the first time high levels of D-dimer in people infected with ZIKV and CHIKV, providing data relevant to the scientific community about the possibility of the association of these arboviruses and the development of venous thromboembolism (VTE).