Análise epidemiológica da doença de chagas em região centro sul de Sergipe

• Ano de defesa: 2020
• Autor(a) principal: Euzébio, Diana Matos
• Orientador(a): Silva, Angela Maria da
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• Palavras-chave em Português: Ciências da saúde; Doença de Chagas em Sergipe; Triatominae; Sorologia; Epidemiologia
• Palavras-chave em Inglês: Health Sciences; Chagas disease in Sergipe; Triatominae; Serology; Epidemiology
• Área do conhecimento CNPq: CIENCIAS DA SAUDE
• Link de acesso: http://ri.ufs.br/jspui/handle/riufs/16870

Introduction: Human Chagas disease, also known as American trypanosomiasis, is a global health issue. About seven million people around the world are infected, according to World Health Organization (WHO). The vector is one of the main transmission routes in Brazil, South and Central American countries. The State of Sergipe has shown a high prevalence of T. cruzi infested triatomines captured between 2013 and 2019, with the villages of Poço da Clara, Alagoinhas and Pilões, in the town of Tobias Barreto, showing the highest registers of the infestation, motivating the epidemiological study. Methods: A cross-sectional study with a quantitative approach was conducted, divided into three stages: the first verified the infection in humans through serological analysis for Trypanossoma cruzi, by at least two laboratory methods, the application of a questionnaire with demographic data and risk variables for the disease. The second stage, after the identification of the risk variables for the transmission of the infection, vectors were searched and captured in the households for entomological and parasitological analysis by LACEN – Sergipe State Central Laboratory. The third stage consisted of the serological evaluation in domestic reservoirs found in the households and peridomiciliary areas.The results were stored in a database in the Excel program, version contained in the Microsoft Office 365 license, analyzed by Epi Info version 7.1.4 and Ambiente R version 3.6.3. The analysis of the variables was performed using the Pearson 's Chi - square test, Monte Carlo simulations were used in the presence of expected frequencies less than 5, and Yates' correction in the opposite case. The analysis of the spatial autocorrelation of the triatomines in the study was performed with GeoDa software version 1.14, using the univariate global Moran index and pseudo-significance test for non-normal distributions.Statistical tests were performed at the 5% probability level, in other words, 95% trust level. Results: Serological evaluation of the population identified 0.24% of T. cruzi infection in humans; serologies from domestic reservoirs were also evaluated. The species Triatoma pseudomaculata, Pantronsgylus lutzi, and Triatoma tibiamaculata were identified in the study sites with higher intradomicilium prevalence. Conclusion: There is chronic human infection of Chagas disease in rural area of Tobias Barreto, south of Sergipe state, in the village of Alagoinhas. There is vector transmission in the studied locations, and the risk is maintained. The results confirm that the disease is not being diagnosed and that vector transmission is not being interrupted, expressing the need for changes in prevention and control policies.