Erythrina velutina Willd : avaliação fitoquímica, farmacológica e biológica

• Ano de defesa: 2010
• Autor(a) principal: Lopes, Clara Raissa de França Rocha e
• Orientador(a): Sousa, Damião Pergentino de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciências Farmacêuticas
• País: BR
• Palavras-chave em Português: Erythrina velutina willd; Constituintes químicos; Triagem farmacológica comportamental; Atividade antimicrobiana
• Palavras-chave em Inglês: Erythrina velutina willd; Chemical constituents; Pharmacological screening; Antimicrobial activity
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: https://ri.ufs.br/handle/riufs/3936

Erythrina plant species, botanical family Fabaceae, are the main source for the tetracyclic erythrina-type alkaloids, and other chemical classes such as flavonoids. The Erythrina velutina Willd specie is popularly known as "Mulungu" and used by the population of the northeastern region of Brazil for its sudorific, soothing, emollient, pectoral, and local anesthetic properties. The objective of this study was to isolate and identify the constituents present in the leaves methanol extract of Erythrina velutina, and to investigate the antimicrobial activity of the crude extract and organic phases as well as contribute to the chemotaxonomy of the genus Erythrina. The leaves were collected in the city of Simão Dias, Sergipe, Brazil. The phytochemical screening performed with the crude methanol extract showed the presence of the following secondary metabolites: alkaloids, tannins, and flavonoids. The crude methanol extract was obtained by maceration and fractionated into hexane, ethyl acetate and n-butanol phase. From the crude methanol extract was extracted alkaloids that resulted on basic chloroform and nbutanol phase. Nicotinic acid was isolated from basic n-butanol phase. The structure identification involved analysis of spectral data of NMR of 1H and 13C and comparison with literature data. The behavior pharmacological screening showed that administration of the organic phases and crude extract promoted discrete behavioral changes at the level of central nervous system, suggesting that the extract of Erythrina velutina contains psychoactive compounds. In addition, antimicrobial screening showed that the crude methanol extract and hexane fraction present a weak inhibition or in part without inhibition zone defined for the fungus Trichophyton rubrum T544.