Perfil auditivo em indivíduos com deficiência isolada do hormônio do crescimento (DIGH)

• Ano de defesa: 2013
• Autor(a) principal: Barreto, Valéria Maria Prado
• Orientador(a): Oliveira, Manuel Hermínio de Aguiar
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Sergipe
• Programa de Pós-Graduação: Pós-Graduação em Ciências da Saúde
• País: BR
• Palavras-chave em Português: Audição; Perda auditiva; Deficiência isolada do hormônio do crescimento; Nanismo hipofisário; Otologia; Otorrinolaringologia; Endocrinologia.
• Palavras-chave em Inglês: Hearing; Hearing loss; Isolated growth hormone deficiency
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://ri.ufs.br/handle/riufs/3567

IGF-I, the circulating effector of growth hormone (GH) action, is essential for differentiation and survival of neurons and maturation of inner ear cells. Isolated GH deficiency (IGHD) represents an ideal model to study the impact of GH/IGF-I axis on hearing. In Itabaianinha County, Northeast Brazil, it had been described the most extend kindred with severe IGHD due to a GH-releasing hormone receptor gene homozygous mutation. (GHRHR). The aim of this transversal study was to evaluate hearing IGHD subjects. 26 IGHD dwarfs individuals (13 females) and 25 controls (15 females) matched by sex and age were studied. They were submitted to a questionnaire on hearing complaints and hearing health history and hearing tests like audiometry, logoaudiometry, acoustic immitance and stapedial reflex. To assess the outer hair cell function in the cochlea, transient evoked otoacoustic emissions (TEOAEs) were done. To assess the auditory nerve and auditory brainstem, auditory brainstem evoked responses (ABR) were obtained. Variables with normal and not normal distribution were compared in the two groups by t test and Mann-Whitney test, respectively. Misophonia and dizziness were more frequent in IGHD than controls (p=0.011). IGHD subjects presented higher thresholds in 250 Hz (p=0.005), 500 Hz (p=0.006), 3 kHz (p=0.008), 4 kHz (p=0.038), 6 kHz (p=0.008) and 8 KHz (p=0.048), and mild high-tones hearing loss (p=0.029).Stapedial reflex (p<0.001) and TEOAEs (p<0.001) were more frequent in controls. There were no statistic differences in ABRs latencies between groups. Hearing loss in IGHD occurred earlier than controls. Conclusions: subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, absence of stapedial reflex and of TEOAEs when compared to normal controls from the same area. Hearing loss in IGHD occurred earlier than controls. These data suggest an effect of the GH-IGF-I axis on hearing function and hearing aging.