Nanopartículas poliméricas baseadas em comonômeros catiônicos para liberação de praziquantel

Detalhes bibliográficos
Ano de defesa: 2018
Autor(a) principal: Alves, Jéssica Bentes
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal do Rio de Janeiro
Brasil
Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia
Programa de Pós-Graduação em Engenharia da Nanotecnologia
UFRJ
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/11422/12487
Resumo: Schistosomiasis is one of the most neglected diseases in the world in which millions of people are infected, but the young children are the most affected by this disease. The treatment is performed with the drug praziquantel (PZQ), which has poorly soluble and a characteristic bitter taste. The PZQ is mainly available in the form of tablets, but there are no specific pediatric formulations. Polymer nanoparticles (PPNs) have great potential as drug carriers, because of their chemical resistance and high rate encapsulation. The main objective of this work is to encapsulate the PZQ in nanoparticles of poly (methyl methacrylate) copolymerized with cationic comonomers (DEAEMA (diethylaminoethyl methacrylate) and DMAEMA (dimethylaminoethyl methacrylate)) by miniemulsion polymerization. PPNs were obtained through different compositions, evaluating the use of a polar and nonpolar initiator and an anionic and cationic surfactant. The PPNs were characterized evaluating the properties of the copolymers, drug incorporation and drug-polymer interaction. Also, PZQ release tests were conducted to analyze the feasibility of the final product. Nanoparticles were obtained with conversion around of 100% and the encapsulation efficiency was greater than 98%. The results obtained show that the different comonomers together with the drug content significantly affect the stability and performance of PPNs.