Contribuição à quimiotaxonomia e ficoquímica de Canistrocarpus cervicornis (Kützing) De Paula & De Clerk (Dictyotaceae) : coletada nos litorais paraibano e fluminense

• Ano de defesa: 2013
• Autor(a) principal: Figueiredo, Camila Silva de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Farmacologia; Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos; UFPB
• Palavras-chave em Português: Phaeophyceae; Dictyotaceae; Canistrocarpus cervicornis; Diterpenos dolastanos; Secodolastanos; Dolastane diterpene; Secodolastane; CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/tede/8056

Marine biodiversity is presented as a promising source of new substances with high biological potential. Among the many organisms that inhabit the marine environment, we stress the brown algae belonging to the family Dictyotaceae. Genus Canistrocarpus was recently established, and some algae Dictyota formerly were reclassified as Canistrocarpus. This work describes the results of the phycochemical study of Canistrocarpus cervicornis (formerly classified as Dictyota pulchella), and the evaluation of the phycochemical profile of C. cervicornis collected on the coast of Paraíba and the coast of Rio de Janeiro, which contributed to the correct name of Dictyota pulchella as Canistrocarpus cervicornis. Alga samples were collected at Bessa Beach (coordinates 07º04'01 '' S and 34º49'35 '' W), city of João Pessoa (PB) in August 2010 and December 2012. The material was dried at room temperature and extraction was performed with CH2Cl2 : MeOH (2:1). The material was dried at room temperature in fresh air and extraction was performed with CH2Cl2: MeOH (2:1). The extract obtained the first collection was subjected to vacuum filtration on silica gel with solvent hexane, ethyl acetate and methanol in increasing gradient of polarity. The fraction hexane : ethyl acetate (85:15) was subjected to column chromatography yielded one new natural product, the dolastane diterpene 4,7-diacetoxy dichotenone A. The extract resulting from the second collection was divided in two parts. The first part was subjected to column chromatography resulted in the isolation of a known dolastane diterpene, 4-acetoxy-14-hidroxydolast-1(15),7,9-triene. A second aliquot of the extract was acetylated and subjected to column chromatography, which led to the isolation of three diterpenes, one dolastane unpublished in the literature, 4-desoxy-amijidictyol and two known secodolastanes, isolinearol acetate and indicol. Chemical constituents isolated were identified by spectroscopic methods 1H and 13C-1D and 2D NMR, optical rotation and comparison with literature data. This study contributed to the chemotaxonomy of the tribe Dictyoteae, especially C. cervicornis.