Efeito da ingestão de salsicha caprina adicionada de quitosana ou quitosana glicosada sobre parâmetros físicos e bioquímicos em ratos dislipidêmicos

• Ano de defesa: 2016
• Autor(a) principal: Dias, Celina de Castro Querino
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Ciências da Nutrição; Programa de Pós-Graduação em Ciências da Nutrição; UFPB
• Palavras-chave em Português: Alimento funcional; Carne caprina; Colesterol; Fibra dietética; Quitosana; Functional food; Goat meat; Cholesterol; Dietary fiber; Chitosan; CIENCIAS DA SAUDE::NUTRICAO
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/tede/8836

Changes in serum triglycerides and lipoproteins are called dyslipidemias, and are directly related to the risk of cardiovascular disease. The fiber intake has positive effects on the control of serum lipoproteins, among them, cholesterol. Chitosan is a biopolymer originated from the alkaline deacetylation of chitin. It is a natural, non-toxic and considered a dietary fiber. The goat meat has excellent lipid profile, as well as essential amino acids, iron and B vitamins Considering the quality of goat meat and chitosan, associated with the potential use of both in product formulation meat was held this objetivando- search to evaluate the effect of the use of goat sausage added chitosan or chitosan glycosylated in dyslipidemic mice. Sausage three formulations were used with similar fat content, differing in the addition or not of 2% chitosan or chitosan derivative. The animals were housed individually in metabolic cages for 42 days and randomly assigned into five groups (n = 10) Control Group (CONT) received water by gavage; Dyslipidemic Group (DLG), received high fat diet; Sausage Group (SG), was added fat diet of goat sausage; Group sausage with Chitosan (SQG), was added fat diet of goat sausage and chitosan; and Group sausage with Chitosan glycosylated (SQGG) received diet-fat adiconada of goat sausage and glycosylated chitosan. During experimeno was accompanied feed intake and weight of the animals and held two colestas stool (21 and 35 days). It was performed oral glucose tolerance test and the end of the experiment were performed murinométricas measurements, checked the weight of visceral fat, dosed biochemical parameters quantified liver fat and cholesterol from the feces and liver. The serum total cholesterol showed lower levels (p <0.05) in the group treated with chitosan glycosylated (82.0 ± 20.7 mg / dl) compared to other treatment groups and higher levels (p <0, 05) for the group that received only caprine sausage (138.9 ± 14.0 mg / dL), as well as the dosage of HDL-c, where SG had 49.8 ± 11.8 mg / dL. For the oral glucose tolerance test, only SQGG (101.5 ± 13.06 mg / dl) showed low glycemic levels at the start of the test. Quantification of liver fat between treatment groups showed a higher content of DLG (6.48 ± 0.66%) and lower content SQG 4.65 ± 0.65%) among treatment groups. SQGG achieved a reduction of visceral fat by up to 46.6% (p <0.05) compared to the control group and showed a reduction of up to 40% of hepatic cholesterol compared to other dyslipidemic groups (p <0.05). All dyslipidemic groups showed elevated fecal cholesterol levels (p <0.05) compared to the control group in both the first and second collection of stools (p <0.05). The consumption of goat sausage provided biochemical benefits to rats, and the sausage added to chitosan and chitosan glycosylated, especially reduction of hepatic cholesterol. Thus, this product can benefit the health of the consumer dyslipidemic.