Ensaio farmacológico clínico com gel do extrato etanólico da casca do caule de Anacardium occidentale L., através da fonoforese no tratamento da síndrome do túnel do carpo

• Ano de defesa: 2019
• Autor(a) principal: Padilha, Janine Agra
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Farmacologia; Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos; UFPB
• Palavras-chave em Português: Anarcadium occidentale L.; Síndrome do túnel carpal; Terapia por ultrassom; Anacardium occidentale L.; Carpal tunnel syndrom; Ultrasound therapy; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/123456789/19203

Known popularly by your anti-inflammatory effects, Anarcadium occidentale Lin. is a tree belonging to the family Anacardiaceae originally from Brazil. The therapeutic ultrasound is an electrophysical resource used by physiotherapists in the treatment of musculoskeletal system affections. The Carpal Tunnel Syndrome is a painful and complex process which is characterized by signals and symptoms related to the compression of the median nerve when it passes through the carpal tunnel in the wrist region. The aim of this study was to evaluate the therapeutic efficiency of the gel obtained from the Anarcadium occidentale L. tree stem bark ethanolic extract, through the phonophoresis, compared to therapeutic treatment using therapeutic ultrasound in patients with Carpal Tunnel Syndrome. This study is a research of the experimental type with a quantitative approach that consisted of a pharmacologic clinical trial, in phase II, random, controlled and double-blind. It was approved by the Ethics Committee of the CCS of the UFPB, being performed at the Laboratory of Analysis of Motion (LAMH), located at the CCS of the UFPB. The sample was formed by 21 volunteers, which were randomized and assessed for the median nerve integrity, pain intensity, degree of muscular strength, inflammatory process intensity and life quality. They were divided in two groups, Group A (UST convencional) and Group B (UST+phonophoresis). For the data descriptive analysis, as well for the Hypothesis Testing execution the software R version 3.4.1 was used. The cut-off point of 5% at the descriptive level (p ≤ 0.05) was considered for statistical significance. Regarding pain and muscular strength assessment, there was a statistically significant difference between the treatment stages for both group A and group B. On the evaluation of the integrity of the median nerve, there was a statistically significant the application of the Phalen Test between the treatment steps for Group A. For the Group B, there was no significant difference between the treatment stages. For the perfomance of the Tinel Sign, there was no statistically significant difference between the treatment stages for any of the groups. On quality of life assessment (SF-36), there was statistically significant difference between the treatment stages for both group A and group B and it was significant difference between the treatments for the domain of “emotional aspects”. On inflammatory process evaluation, there was no significant difference between the treatment stages for any of the groups. There was no significant difference between the treatment stages for any of the groups, regarding pain assessment, median nerve integrity, muscular strength and thermography. It is hoped that this study will contribute to scientific knowledge about Anacardium occidentale L., once that its pharmacological properties are so well known that it makes it a plant of great use in popular medicine.