Compostos bioativos das partes aéreas de Evolvulus linarioides

• Ano de defesa: 2021
• Autor(a) principal: Pereira, Laiane Caline Oliveira
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal da Paraíba; Brasil; Farmacologia; Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos; UFPB
• Palavras-chave em Português: Evolvulus linarioides; Convolvulaceae; Atividade anti-inflamatória; Derivados do hamamelitol; Anti-inflammatory activity; Hamamelitol derivatives; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
• Link de acesso: https://repositorio.ufpb.br/jspui/handle/123456789/22068

Three new caryophyllane-type sesquiterpenoids, linariophyllenes A−C (1−3), two new hamamelitol derivatives, linaritols A (4) and B (5), two new chromones, linariosides A (6) and B (7), and three known chromones, cnidimol C (8), monnieriside A (9), and undulatoside A (10), were identified from the aerial parts of Evolvulus linarioides. The structures of these compounds were elucidated by NMR, MS, and IR data. The absolute configurations of compounds 1−5 and 7 were established via electronic circular dichroism data. The anti-inflammatory potential of compounds 1−5 and 7−10 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and proinflammatory cytokine IL-1β by stimulated J774 macrophages. Compounds tested at noncytotoxic concentrations inhibited NO production by macrophages, exhibiting IC50 values between 17.8 and 66.2 μM, and inhibited IL-1β production by stimulated macrophages by 72.7−96.2%.