Detalhes bibliográficos
| Ano de defesa: |
2019 |
| Autor(a) principal: |
Barcellos, Jiames Nunes |
| Orientador(a): |
Fernandes, Liana da Silva |
| Banca de defesa: |
Praetzel, Juliana Rodrigues,
Mortari, Sérgio Roberto |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso embargado |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Franciscana
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/902
|
Resumo: |
Tricresol formalin consists of 90% formaldehyde and 10% cresols. It is highly volatile, has a remote action and has been used in endodontics since the twentieth century and it is still being used in Brazil for endodontic treatment of necrotic teeth with periapical lesions as intracanal medication between sessions. There is still controversy as to the biological compatibility in the conditions of clinical use of this drug, because the studies conducted on this substance and its components do not match its clinical use, most of them considering its use in pediatric dentistry; which is placed over the vital pulp. Tricresol formalin is reported as a potential cytotoxic substance because when in direct contact with cells it is responsible for producing a cytogenotoxic response. An alternative to increase stability and ensure their safe administration in direct contact with cells would be use nanotechnology, as the use of nanomaterials provides numerous advantages such as increased solubility, controlled release of the active, among others. In this study we aimed to promote a controlled release of the drug through the production and characterization of a nanostructured system containing tricresol formalin as active, as well as to evaluate the cytogenotoxic profile of the produced formulation. As a result of this research, we were successful in the preparation, optimization of the preparation method and characterization of the tricresol formalin-containing nanomaterial. The formulation used in this work showed no toxic behavior against human peripheral blood mononuclear cells and showed a significant reduction of tricresol formalin toxicity in human fibroblast cells. The produced nanostructures presented values similar to free form for antimicrobial activity. Thus, it is evident that the produced nanostructured system containing tricresol formalin may become a safer alternative for use within endodontics. |
