Detalhes bibliográficos
| Ano de defesa: |
2024 |
| Autor(a) principal: |
Santos, Luíza Savio |
| Orientador(a): |
Santos, Cláudia Lange dos |
| Banca de defesa: |
Rupp, Caroline Jaskulski,
Machado, Alencar Kolinski |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Franciscana
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Nanociências
|
| Departamento: |
Biociências e Nanomateriais
|
| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://www.tede.universidadefranciscana.edu.br:8080/handle/UFN-BDTD/1313
|
Resumo: |
Annually, more than 17 thousand women are diagnosed with cervical cancer in Brazil. This type of malignant tumor is located in the lower part of the uterus and is directly associated with persistent infection of the HPV virus. The treatments used to address this disease can bring numerous side effects ranging from hair loss, nausea, and loss of appetite to early menopause, which occurs when a total organ removal (hysterectomy) is performed. In this context, there is a need to seek new treatments that can both alleviate such adverse effects, thus allowing for a better quality of life for patients, and improve the efficiency of existing treatments. One of the possibilities that can be explored is the use of nanomaterials. In this study, we investigated, through first-principles calculations, the interaction of graphene oxide (GO) and chitosan (CSNP) nanoparticles with the chemotherapeutic drugs carboplatin (CAP) and cisplatin (CP), commonly used in conventional chemotherapy nowadays. The results showed that the systems interact through physical bonds, without substantial chemical and structural alterations, making these systems interesting for targeted drug delivery. Subsequently, we studied, via molecular docking, the interaction of the most favorable systems, obtained through ab initio calculations, with the E6 oncoprotein, known for its role in the development and progression of cervical cancer. Overall, all interactions (GO+CAP, GO+CP, CSNPs+CAP, and CSNPs+CP) obtained van der Waals interactions, π-π type interactions, chain-specific interactions, and conventional hydrogen bonds. We believe these results are promising for the development of nanomaterials to be used in cancer treatment. |
