Efeitos de componentes solúveis e celulares no leite humano sobre Streptococcus mutans

• Ano de defesa: 2017
• Autor(a) principal: Borges, Fabiana Custódio
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Instituto de Ciências Biológicas e da Saúde (ICBS) – Araguaia; UFMT CUA - Araguaia; Programa de Pós-Graduação em Imunologia e Parasitologia Básicas e Aplicadas
• Palavras-chave em Português: Cárie dentária; Células; Leite materno; Opsoninas; CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA; Dental cavity; Cells; Breast milk; Opsonins
• Link de acesso: http://ri.ufmt.br/handle/1/4463

Dental caries is a chronic, infectious and transmissible disease most common in childhood. The major microorganisms that cause caries are streptococci of the mutans group, especially Streptococcus mutans. Literature work has associated with infection of children to their caregivers and breastfeeding. On the other hand, human colostrum and milk have bioactive and soluble components that play a protective role for various microorganisms. It is possible that cellular interactions with soluble components present in the secretion exert effects during the processes of caries formation in infants. The present work verified the effects of breastfeeding on the development of caries, as well as the functional activity of phagocytes and soluble components of human colostrum for S. mutans. Males and offspring were divided into four groups - Children aged 6 to 35 months who were breastfed, children from 36 to 71 months who were breastfed, children from 6 to 36 who were being breastfed and children from 6 to 71 months who were not breastfed. Also colostrum samples were collected from 30 nursing mothers and blood samples from six males. The concentration of IgA, IgG, C3 and C4 was evaluated in the supernatant of colostrum and human serum. A pool of normal human serum and pool of supernatant was also prepared for use as the source of opsonins. In colostrum and blood cells, the release of superoxide anion, phagocytosis and microbicidal activity for S. mutans was checked. Salivation of the S. mutans colonization of mothers and their children for the different groups, the amount of IgA. It was observed that breast milk had a protective effect against S. mutans, and the group of children with There was an increase (p <0.05) in the release of superoxide anion and phagocytosis when the colonic and blood mononuclear cells (MN) were opsonized with supernatant of human colostrum in the presence of When the blood cells were evaluated, they observed an increase (p <0.05) in phagocytosis and microbicidal activity independent of the type of opsonization. These data suggest that the soluble and cellular components present in the secretion act in a beneficial way towards protection for dental caries and probably this early stimulation is fundamental for the adequate development of the oral cavity.