Detecção do vírus da cinomose em cães naturalmente infectados no Mato Grosso

• Ano de defesa: 2014
• Autor(a) principal: Lopes, Leticya Lerner
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Agronomia, Medicina Veterinária e Zootecnia (FAMEVZ); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências Veterinárias
• Palavras-chave em Português: Vírus da cinomose canina; Gene H; Imuno-histoquímica; Sinais neurológicos; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA; Canine distemper virus; Hemagglutinin (H) gen; Immunohistochemistry; Neurologic signs
• Link de acesso: http://ri.ufmt.br/handle/1/535

Canine distemper virus (CDV) is a RNA virus classified under the genus Morbillivirus within the family of Paramyxoviridae. The time of onset of the immune response and, likely, also the virulence of the virus are critical factors in the extent of viral invasion of epithelial tissues and of the central nervous system. The CDV is the most responsible of encephalitis in dogs from different ages. In this study, the aim was to detected CDV in dogs with neurologicals signs referred for necropsy at the Laboratory of Veterinary Pathology, Federal University of Mato Grosso (LPV-UFMT).Over a period of 1 year, 85% (68/80) of the dogs necropsied had microscopic lesions compatible encephalomyelitis by CDV. Which 67.6% (46/68) were confirmed by immunohistochemistry (IHC). Microscopically, the CNS lesions were classified demyelinating encephalitis in 15.2% (7/46) to acute, 73.9% (34/46) in subacute and 10.8% (5/46) to chronic. The cerebellum (97.8%) was the main target organ to verify positivity in the IHC. Canine distemper virus is a pathogen responsible for neurological clinical signs in dogs mainly under one year of age. Distemper demonstrated its relevance within the canine population of Cuiabá, being necessary to our understanding, characterizing the viral strain related to the region.