Avaliação do estresse oxidativo em músculos soleus e extensor longo dos dedos de ratos submetidos a dieta hipoproteica e hiperglicídica logo após o desmame

• Ano de defesa: 2017
• Autor(a) principal: Silva, Flavia Hosaki Silvino da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Faculdade de Medicina (FM); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Ciências da Saúde
• Palavras-chave em Português: Dieta hipoproteica e hiperglicídica; Estresse oxidativo; Músculo esquelético; CNPQ::CIENCIAS DA SAUDE; Low protein high - carbohydrate diet; Oxidative stress; Skeletal muscle
• Link de acesso: http://ri.ufmt.br/handle/1/4449

The aim of this study was to evaluate the oxidative stress and antioxidant defense in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity in the soleus muscles by 50%. There was an increase in the carbonylated proteins with no increase in malonaldehyde content. Despite the 22% increase in xanthine oxidase activity, the activity of the antioxidant enzymes also increased significantly. The LPHC diet increased the malonaldehyde levels in EDL muscles by 80% in addition to a 66% increase in XO activity with no alterations in antioxidant enzyme activity except for glutathione peroxidase. The GSH/GSSG ratio was lower in both muscles. These results suggest that the soleus muscle responds better to increasing ROS production.