Síntese, caracterização e avaliação do potencial antitumoral de compostos de coordenação de Ru+3 com Bipiridina e L-Triptofano

• Ano de defesa: 2017
• Autor(a) principal: Moraes, Fabricio Tarso de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Mato Grosso; Brasil; Instituto de Ciências Exatas e da Terra (ICET); UFMT CUC - Cuiabá; Programa de Pós-Graduação em Química
• Palavras-chave em Português: Rutênio; Antitumoral; Aminoácidos; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA; Ruthenium; Antitumor; Amino acids
• Link de acesso: http://ri.ufmt.br/handle/1/1611

In order to synthesize, characterize and evaluate the antitumor potential of ruthenium-derived compounds, was created in this work, from the K[Ru(bipy)Cl4] precursor, a simple and reproducible synthesis route for a new Ru+3 coordination compound with bipy and L-trip. The spectroscopic characterization gives strong indications of the Ru-(L-trip) interaction. The displacement of the band corresponding to the carboxylate ion to higher energies in the FTIRmed, and the band displacements referring to the aliphatic amine, indicates a bidentate coordination of the L-trip ligand. The presence of chlorine in the coordination sphere is demonstrated by the absorption band at 433 nm in the UV-VIS spectrum. In addition, the transition bands at 496 and 601 nm, referring to MLCT transitions that are not observed in striker K[Ru(bipy)Cl4], confirm the presence of L-trip linker in the coordination sphere. With the studies in thermoanalytical techniques it was possible to suggest the minimum formula of the compound, [Ru(bipy)(L-trip)Cl2].1/2H2O. Due to the solubility problems encountered, analysis of the antitumor potential of the compound [Ru(bipy)(L-trip)Cl2] became infeasible. However, the evaluation of the antitumor potential of K[Ru(bipy)Cl4] demonstrated that it has considerable toxic effects on the MCF-7 cell line but did not show selectivity and reach PBMC cells in the same proportions.