Detalhes bibliográficos
| Ano de defesa: |
2023 |
| Autor(a) principal: |
Rogerio Carlos Sanfelice Nunes |
| Orientador(a): |
Rodrigo Juliano Oliveira |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Tese
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Fundação Universidade Federal de Mato Grosso do Sul
|
| Programa de Pós-Graduação: |
Não Informado pela instituição
|
| Departamento: |
Não Informado pela instituição
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Link de acesso: |
https://repositorio.ufms.br/handle/123456789/6049
|
Resumo: |
Piper glabratum is a plant traditionally used for the treatment of pain and inflammation.This plant is ever consumed by pregnant women.The effects of the etanol extract of Piper glabratum (EEPg) leaves on the reproductive performance and embryofetal development of Swiss mice were evaluated.Pregnant females were treated with 100,1.000 and 2.000 mg/kg throughout the gestational period per gavage.The control group received distilled water in the proportion of 0,1ml/10g.The results showed that EEPg has a low maternal-toxic potential and does not alter the reproductive performance off emales.However,it altered embryofetal development and caused fetal weight reduction in the two highest doses.In addition,it interfered with placental weight,placental index and placental efficiency.The frequency of visceral malformations increased by 2,48, 1,89 e 2,11 with the dosages of 100,1.000 and 2.000 mg/kg of EEPg respectively.It was observed that 100% of the offspring treated with EEPg showed changes in the ossification process.Therefore,it is considered that EEPg has a low maternal-toxic potential and does not alter the reproductive performance of females.However, it is teratogenic and interferes mainly in the ossification process and therefore its use is contraindicated during pregnancy. |
