Efeitos dos extratos de aiouea trinervis e guarea kunthiana sobre as formas epimastigotas de trypanosoma cruzi

• Ano de defesa: 2016
• Autor(a) principal: Pereira, Tiago de Andrade
• Orientador(a): Ferreira, Alda Maria Teixeira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Doença de Chagas; Extratos Vegetais; Lauraceae; Meliaceae
• Link de acesso: https://repositorio.ufms.br/handle/123456789/2854

After a century of Chagas disease discovery there are about six million people infected with Trypanosoma cruzi, mainly living in the American continent. In Brazil, is estimated to be three million people infected. The drugs used for the treatment of Chagas disease are partially effective in acute and ineffective in the chronic phase of the disease, and cause side effects and systemic toxicities. It is known that natural products are an attractive source compounds with many structures which display potent biological activities and pharmacological profiles and this fact has been shown by several studies to assess the anti-Trypanosoma action of several products from plants. This study evaluated the effect of ethanol extracts of Aioueae trinervis and Guarea kunthiana on growth, morphology and membrane integrity of epimastigotes forms of T. cruzi Dm28. The data revealed that both extracts inhibit the growth of the parasites caused dramatic morphological changes such as increased of flagellum length, reduction of kinetoplast area, reduction of the circumference and width of the cell. The treatment of parasites with G. kunthiana extract induced the membrane permeabilization, affecting the cell viability. These results suggest that there are compounds with anti-Trypanosome activities in the extracts evaluated.