Síntese de macrociclos derivados de D-glicosamina.

• Ano de defesa: 2009
• Autor(a) principal: Magno Carvalho Pires
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: macrociclos; ciclização radicalar; Carboidratos; glicosamina; Síntese orgânica; Química farmacêutica; Química orgânica; Farmácia
• Link de acesso: http://hdl.handle.net/1843/FARD-82KM3T

The macrocycles form an important class of compounds that, by having various biological activities and many drugs available, are targets of intense research. The challenge of synthesizing macrocycles via short and efficient synthetic routes, with yields that made possible the assessment of organic compounds, were the goals of this work.Two glycosides were synthesized from D-glucosamine by four steps. These glycosides were submitted to Bu3SnH/AIBN-mediated radical carbocyclization reactions to furnish three macrocycles and two products of aromatic radical substitution.