Reabsorções radiculares externas após o reimplante de dentes permanentes avulsionados: ocorrência e associação com fatores demográficos, clínicos e genéticos

• Ano de defesa: 2016
• Autor(a) principal: Daniela Augusta Barbato Ferreira
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Reabsorção radicular externa; Reimplante; Polimorfismos genéticos; Interlrucina-10; RANK/RANKL/OPG; Interleucina 10; Polimorfismo (Genética); Reimplante dentário; Reabsorção da raiz (Dentes)
• Link de acesso: http://hdl.handle.net/1843/ODON-ACQPLN

External root resorption (ERR) is a serious complication following replantation and its progressive inflammatory and replacement forms are significant causes of tooth loss. This retrospective study aimed to evaluate the factors related to the occurrence of Inflammatory External Root Resorption (IERR) and Replacement External Root Resorption (RERR) shortly after permanent tooth replantation in patients treated at the Dental Trauma Clinic at the School of Dentistry of Federal University of Minas Gerais (DTC SD FUMG) in Belo Horizonte, Brazil. Case records and radiographs of 269 teeth from 208 patients were evaluated for the presence, type, and extension of ERR and tested for their association with age, clinical factors related to the management and acute treatment of the avulsed tooth and the presence of SNPs rs1800896 in the IL-10 (rs 1800896), RANK (rs 8086340), RANKL (rs 2277438) e OPG (rs 2073618). A multivariate Poisson Regression in the GEE model was performed to teste the effect of age, clinical and genetic factors in the occurrence and extention of ERR. The patients age at the moment of trauma and time elapsed between replantation and the onset of endodontic therapy had a marked effect on the ERR prevalence and extension. The progression rate of IERR was 50% higher in patients younger than 11 years when compared to that of patients older than 11 years at the time of trauma (p<0.001). When considered the cutoff point of 16 years, the age effect was more pronounced showing highest rates of reabsorption of both RREI as RRES in patients under 16 years than in patients over 16 years at the time of trauma. The results showed that the time elapsed between replantation and the onset of endodontic therapy progressively affected the prevalence and severity of ERR and was directly proportional to the increase in rates of reabsorption. To study the effect of age, clinical and genetic variables in the type of ERR observed at the onset of endodontic therapy a multivariate logistic regression model in the GEE model was performed. The presence of the allelic variant C + (CC + CG) in SNP rs 2073618 of the gene encoding OPG was significantly associated with the occurrence of IERR (p = 0.022). It was concluded that while demographic and clinical factors did not influence the type of RRE after replantation of permanent teeth, the occurrence and the indexes were strongly influenced by the time elapsed between the replantation and the beginning of the endodontic treatment and the age of the patient time of injury. On the other hand, genetic factors were significantly associated with the type of resorption observed but did not affect.