Anemia na malária vivax: perfil de anticorpos IgG e IgM contra moléculas de superfície de hemácias de diferentes grupos sanguíneos do sistema ABO

• Ano de defesa: 2016
• Autor(a) principal: Jamila da Silva Sultane Aboobacar
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Parasitologia
• Link de acesso: http://hdl.handle.net/1843/BUBD-AHRM7S

The destruction of uninfected RBCs has been associated with anemia in malaria but the mechanisms involved in this clearance remain unknown, particularly in regard to P. vivax. One of the factors that could contribute to this destruction is self-antibodies produced during the infection. However, few studies have concerned the relationship between autoimmunity and anemia in P. vivax infections. The aim of this study was to evaluate the associations between IgG or IgM antibody responses against erythrocytes from different blood groups (A, B and O) and anemia in patients infected with P. vivax. For this, Cell-ELISA assays were performed using erythrocytes from healthy individuals never exposed to malaria and whose blood groups were A, B or O. Patients with uncomplicated vivax malaria residing in low-endemic areas in the Brazilian Amazon (n = 75) and patients with severe malaria living in an intense transmission area of malaria in Peru (n = 18) were also included. It has been found that for patients with non-severe malaria, the recognition by antibodies IgG against blood group A erythrocytes molecules was lower than that observed for the B and O. On the other hand, with regard to the IgM response, it was observed that the red blood cells of group B were less recognized in comparison to erythrocytes from the other blood groups. Moreover, when non-severe patients were evaluated, no significant association was found between exposure or parasitaemia and antibody response against red cell molecules of different blood groups. In addition, negative associations between hemoglobin and IgG or IgM antibodies were observed. When IgG or IgM antibody responses were compared between anemic and non-anemic patients, we observed that both responses were higher for the anemic patients. By the other hand, different results were found for patients with severe malaria living in Peru, since it was reported that in this area the anemic patients had lower levels of IgM and IgG than those observed for the non-anemic. All these findings increase our understanding of the relationship between antibody responses directed against erythrocytes of different blood groups and anemia in vivax malaria.