Efeitos agudo e crônico do treinamento de força na musculação sobre os níveis plasmáticos e urinários de moléculas do Sistema Renina Angiotensina em homens jovens e saudáveis

• Ano de defesa: 2019
• Autor(a) principal: Marcelo Henrique Salviano de Faria
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; Brasil; MEDICINA - FACULDADE DE MEDICINA; Programa de Pós-Graduação em Medicina Molecular; UFMG
• Palavras-chave em Português: Força Muscular; Educação Fisica e Treinamento; Hipertrofia; Agiotensina II; Angiotensina 1-7; Treinamento de Resistência; Agiotensinas
• Link de acesso: http://hdl.handle.net/1843/31119

The importance of physical exercise for a healthy lifestyle is well understood. There are different types of exercising protocols, including high intensity intermittent training, endurance, and strength training (ST). It is known that ST can modulate regulatory systems. However, there are very few studies regarding the interactions between ST and renin angiotensin system (RAS) in humans. Here, we investigated the effect of ST on levels of RAS molecules in urine and plasma. Twelve male volunteers with 23.4±2.7 years old performed our ST protocol for 10 weeks (three times a week), which consisted of 3 sets at 65% of one maximum repetition (1MR) of 3 leg exercises, pause of 90” between sets, and time duration of repetition of 5”. The effect of ST was evaluated on circulating leukocytes count, urinary and plasma levels of RAS molecules, including Angiotensin (Ang) II, Ang-(1-7), angiotensin converting enzyme (ACE) 1 and ACE 2, before and immediately after the first (S1) and the last (S30) session of training. The level of strength significantly increased in last training session as compared to first session. Exercise acutely increased post-training blood lactate levels and leukocyte count. The training protocol significantly reduced the percentage of fat and increased the total lean mass. Regarding RAS molecules, plasma levels of Ang II were higher after the last session in comparison to levels before this session and also if compared to values after the first session of exercise. Levels of Ang-(1-7) significantly increased in plasma and urine after first and last sessions and in the comparison of values before and after last session to those before and after first session, respectively. Levels of ACE1 and ACE2 did not modify in any condition. In conclusion, plasma and urinary concentrations of Ang II and Ang-(1-7) were modified by ST. The effect on Ang-(1-7) was also observed in baseline levels before last exercise session.