Prevalência de dispepsia funcional em pacientes com doença hepática gordurosa não-alcóolica

• Ano de defesa: 2015
• Autor(a) principal: Erika Cristina Lima
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Ciências Aplicadas à Súde do Adulto; Hepatopatia gordurosa não alcoólica; Dispepsia; Gastroenteropatias; Sinais e sintomas digestórios; Estudo observacional; Fígado gorduroso
• Link de acesso: http://hdl.handle.net/1843/BUOS-AJ8MNN

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. The relationship between NAFLD and the incidence of functional dyspepsia (FD) has not yet been studied. The purpose of the present study is to evaluate the association between NAFLD and FD. Methods: In an observational, cross-sectional study, 100 adult patients with NAFLD (AGA criteria) and 107 controls (HC) were included. All participants were questioned and scored for gastrointestinal (GI) symptoms according to Rome III criteria. NAFLD score, upper endoscopy and glucose hydrogen (H2) breath test were performed in all NAFLD patients. Patients with peptic ulcer or erosive duodenitis were excluded. Metabolic syndrome (MS) was defined using NCEP (ATP III). Results: NAFLD and HC groups included 96 and 105 patients, mean age 55.9±12.7 yrs. vs. 55.2 ±12.8 yrs. (p: NS), 19% vs. 22% males (p: NS) respectively. Hypertension was present in 70,5% vs. 34.3 (p<0.001),Diabetes 42.1% vs. 13.3% (p<0.001) and MS 74.7% vs. 12.4% (p <0.001). The frequency of GI symptoms were: FD (28.1% vs.13.3%, p=0.009), Postprandial Distress Syndrome (25% vs.11.4%, p=0.012), Postprandial Fullness (19.8% vs.10.5%, p=0.064), Early Satiation (9.4% vs.5.7%, p=0.324), Epigastric Pain Syndrome (1.0% vs.0.0%, p=0.478) Epigastric Burning or Pain (18,8% VS. 6,7%, p=0,010). FD (OR 1.143, CI 1.014-1.287), Central obesity (OR 1.658, CI 1.481-1.856), Hypercholesterolemia (OR 1.242, CI 1.095-1.408), Low HDL cholesterol (OR 1.238, CI 1.090-1.406) remained significant on multivariate analysis. Small intestinal bacterial overgrowth (SIBO) was detected in 16.48% of NAFLD patients and was not associated with GI symptoms. Conclusion: This study characterizes for the first time the high frequency of functional dyspepsia, according to Rome III, in patients with NAFLD. A greater knowledge of the GI symptoms associated with NAFLD will be important in the clinical management of these patients