Avaliação de marcadores tumorais sérios em cadelas com e sem metástase em câncer de mama

• Ano de defesa: 2010
• Autor(a) principal: Liliane Cunha Campos
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: cadela; câncer; perfil proteico; mama; marcador tumoral; Neoplasias da mama/patologia; Avaliação nutricional; Proteínas séricas; Neoplasias mamárias experimentais; Recidiva local de neoplasia; Marcadores biológicos de tumor
• Link de acesso: http://hdl.handle.net/1843/BUOS-8M4HDH

Tumor markers are substances present in the tumor, blood or other fluids produced by it primarily or secondarily by the patient, in response to the presence of tumor. In medicine, serum biomarkers CEA, CA15.3 and enzymes LDH and alkaline phosphatase assist in prognosis, therapy monitoring and detection of breast cancer recurrence in women, while the levels of total protein and albumin help assess the nutritional status of the patient. In veterinary medicine, these biomarkers are rarely studied. The aim of this study was to determine and evaluate the serum concentrations of CEA, CA15.3, alkaline phosphatase and LDH in healthy female dogs and female dogs with breast cancer with and without metastases, and observe the correlation between tests CEA and CA15.3 and the disease staging, and to determine the protein profile of these patients by dosage serum total protein and albumin. We evaluated 69 dogs and 10 healthy, 41 with mammary cancer without metastases, nine with mammary cancer and regional metastasis and nine with mammary cancer and distant metastasis. Serum concentrations of CEA, LDH and alkaline phosphatase showed no significant differences (p> 0.05) between groups. However, the biomarker CA15.3 in the group of female dogs with mammary cancer and distant metastasis increased significantly (p = 0.029) compared with other groups, suggesting an association of this tumor marker with clinical staging of breast cancer in female dogs. The marker CA15.3 showed low correlation with CEA, suggesting a greater sensitivity to tumor evolution. In assessing the protein profile, only to albumin showed significant difference (p <0.05) in group of female dogs with cancer without metastasis