Avaliação da motricidade ocular, cognição e comportamento na coreia de Sydenham, doença de Huntington e Neuroacantocitose

• Ano de defesa: 2016
• Autor(a) principal: Tiago Mendonça Attoni
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Núcleos da base; Coreia de Sydenham; Neuroacantocitose; Huntington; Doença de; Neurociências
• Link de acesso: http://hdl.handle.net/1843/BUBD-AHVMYS

INTRODUCTION: Involvement of the basal ganglia (BG) occurs in neurological diseases such as Sydenham's chorea (SC), Huntingtons disease (HD), and Neuroacanthocytosis (NA). SC is a neurological manifestation of rheumatic fever (RF), where chorea is associatedwith other findings such as carditis and arthritis. HD is characterized as neurodegenerative inherited disease, with the presence of movement disorders and behavioral disorders. NA denotes a heterogeneous group of diseases, which characterizes it as a syndrome. This is a group of rare diseases, with acanthocytosis, progressive cognitive loss, chorea and other abnormal movement disorders. As a result of the functionaldivision between the BG circuits it is possible for a dysfunction to be reflected in ocular motility, cognition and the behavior in a relatively proportionalway. OBJECTIVES: To evaluate the ocular motility, cognitive and behavioral functions of patients diagnosed with SC, HD e NA. METHODS: This stud evaluated 20 patients with SC, 22 HD patients and 11 patients with NA. Besides the electrophysiological evaluation of ocular motility, testswere applied to evaluate the overall cognitive performance, executive functions, cognitive speed and behavior. RESULTS: Patients with HD showed greater impairment in ocular motility function, cognition and behavior, when compared with the control group (CG), and groups with SC and NA. In SC changes were identified in the speed of the saccadic movement, the movement of pendulum tracking and latency antisaccade movement. Changes in this group were also found in executive functions and behavioral assessment. In NA there were no changes in the speed of saccadic movement, the movement of pendulum tracking and latency antisaccade movement. These individuals showed changes in executive functions and behavioral assessment. CONCLUSIONS: The study results support the hypothesis that these three choreatic diseases have simultaneous and variable impairment of frontostriatal circuits motor, oculomotor, cognitive and limbic.