Temperamentos afetivos: aspectos genéticos, familiaridade e aplicação na clínica dos transtornos de humor

• Ano de defesa: 2013
• Autor(a) principal: Alexandre de Aguiar Ferreira
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: BDNF; Transtornos do humor; Resposta ao antidepressivo; TEMPS-Rio de Janeiro; Temperamentos afetivos; Sintomas afetivos; Neurociências; Questionários; Estresse psicológico; Família; Psicoterapia
• Link de acesso: http://hdl.handle.net/1843/BUBD-9EFH39

The affective temperament profiles have been proposed as an important issue in the psychopathology of mood disorders. The brief Brazilian version of TEMPS-A -TEMPS-Rio de Janeiro identifies the affective temperament profiles in six types: depressive, cyclothymic, irritable, hyperthymic, anxious and worrying temperaments. The first aim of this study was evaluate the affective temperaments among mood disorder patients, their relatives and normal controls and perform a comparison between these groups. The influence of affective temperament in antidepressant response and the association between affective temperament profiles and BDNF, and COMT genetic polymorphisms were other aims of this study. The global sample was composed by 446 participants. 178 patients [90 diagnosed as bipolar (BD) and 88 as major depressive disorder (MDD) patients] were evaluated. All patients have taken antidepressant by at least eight weeks. The affective temperament profiles of 132 first degree relatives of these patients (HRP group) and 136 normal controls (NC) were too evaluated. The clinical group showed higher temperament scores than HRP and NC, except for hyperthymic scores. BD patients showed higher cyclothymic, hyperthymic and lower anxious scores than MDD patients. In the comparison between relatives of bipolar patients and the relatives of MDD patients and NC group, higher cyclothymic scores were found in bipolar relatives. About the antidepressant response issue, the absence of response was associated with depressive and anxious temperament. Among bipolar patients, antidepressant-induced mania was associated with higher scores in hyperthymic and cyclothymic subscales. Another finding was the association between hyperthymic temperament type and better antidepressant response in MDD patients. In the genetic analysis performed in the clinical population, we found a trend (P = 0.054) association of depressive temperament with presence of the Met allele of the BDNF Val66Met polymorphism. Therefore, the affective temperaments traits have familial aspects, thus lending further support to future research to identify genetic and neurobiological factors which could be associated to its constitution. Our data support that affective temperaments might become an useful tool for clinical characterization and therapeutic response evaluation in mood disorders.