Estudo da correlação entre o índice ponderal e a concentração de leptina materna e fetal em gestantes diabéticas e não diabéticas

• Ano de defesa: 2004
• Autor(a) principal: Sivana Santos Assreuy Diniz
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Indice ponderal neonatal; Diabetes; Leptina; Gravidez em diabéticas; Diabetes na gravidez; Peso-estatura/fisiologia; Estudo comparativo; Diabetes mellitus; Peso ao nascer; Recém-nascido; Gravidez
• Link de acesso: http://hdl.handle.net/1843/BUBD-A32JPU

OBJECTIVE: verify correlation existence between neonatal ponderal index (IP) and leptin concentration, maternal and fetal, in pregnant healthy and diabetics; verify if in the patients' diabetic group, the insulin use interferes in the correlation between IP and leptin concentration, maternal and fetal. SUTDY DESIGN: this is a cross-sectional study carried out from March 2001 to February 2003, in which 62 gestations were evaluated, being 30 healthy patients (control group) and 32 diabetic (study group), subdivided in users (17 patients) and not insulin users (15 patients). Were collected samples of maternal blood and of the umbilical cord blood at delivery, for posterior determination of leptin concentrations in maternal and fetal, arterial and venous, through conventional enzymatic radioimunnoassay (RIA). The IP was obtained dividing the weight of the newborn (grams) by the stature (cm) to the cube and multiplied by 100. It used Pearson's Correlation for evaluation the correlation existence between leptin concentration and IP. All the results were considered significant for a probability lower than 5% (p < 0,05), confidence interval at least 95%, for the conclusions. RESULTS: It was verified positive significant correlation between IP and leptin concentration in the cord blood, arterial (p=0,048) and venous (p=0,020) in the group study. It observed a tendency to positive correlation between IP and maternal leptin concentration in this group (p=0,07). When evaluated the diabetic subgroups users or not of insulin, correlation between IP and cord blood leptin concentration did not keep, just presenting tendency to this correlation among insulin users (arterial p=0,077 and veined p=0,078). In this same group was verified positive significant correlation between maternal leptin concentrations and IP (p=0,008). CONCLUSIONS: There is positive correlation between IP and maternal leptin concentration in insulin diabetic pregnant users; there is positive correlation between IP and fetal leptin concentration, arterial and venous, in pregnant diabetics. The need to insulin use could have interfered in this correlation.