Efeito de terapias de estimulação mecânica e elétrica no fluxo salivar, na mucosite oral induzida por quimioterapia e no nível de citocinas na saliva de pacientes submetidos a TCTH

• Ano de defesa: 2010
• Autor(a) principal: Tania Mara Pimenta Amaral
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: transplante alogênico de células tronco-hematopoiéticas; mucosite oral; estimulação salivar; Estomatologia; Odontologia
• Link de acesso: http://hdl.handle.net/1843/ZMRO-8EEMVY

Objective. To evaluate the effects of salivary stimulation therapies on salivary flow, oral mucositis and salivary cytokines levels in patients receiving allogeneic hematopoietic stem cell transplantation. Study Design. Thirty-five patients were randomized into three groups categorized by type of salivary stimulation: Hyperboloid, transcutaneous electrical nerve stimulation (TENS), combination of these two therapies and control group. Resting and stimulated saliva were collected from 7 days before to 14 days after transplantation. Salivary cytokines were assessed by ELISA. Results. The TENS and TENS+Hyperboloid groups were less affected by the reduction of resting salivary flow and also showed a tendency to keep higher rates of stimulated salivary flow in relation to the controls. Therapy groups had lower incidences of oral mucositis in grades 3 and 4. The TENS and TENS+Hyperboloid group tended to show a reduction of MMPs and increased of EGF levels. Conclusion. Salivary stimulation therapies contributed to minimize the reduction of salivary flow and severity of chemotherapy-induced oral mucositis.