Lúpus eritematoso sistêmico: avaliação do estado nutricional, da atividade física e dos fatores associados ao excesso de peso

• Ano de defesa: 2010
• Autor(a) principal: Fabiana de Miranda Moura
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Minas Gerais; UFMG
• Palavras-chave em Português: Avaliação nutricional; Atividade física; Lúpus eritematoso sistêmico; Excesso de peso; Lúpus eritematoso; Estado nutricional; Atividade motora; Exercício; Lúpus eritematoso sistêmico/complicações; Obesidade
• Link de acesso: http://hdl.handle.net/1843/BUOS-8KVNUU

Introduction: Patients with systemic lupus erythematosus (SLE) may present nutritional changes triggered by the disease or its treatment, and these conditions can interfere with their prognosis. Two third of patients with systemic lupus erythematosus (SLE) present excess weight and 30% of those are obese. However, the effect of excess weight on the evolution of patients with SLE is unknown. Objective: To assess the nutritional status, physical activity among SLE patients. To determine the clinical-laboratorial findings, socio-demographic characteristics and treatment as well as associated factors in SLE patients with excess weight. Methods: 170 women with ages between 18 and 60 years were assessed in this cross-sectional study. The nutritional status, clinical-laboratorial findings, socio-demographic characteristics and treatment of disease were assessed. Results: The mean (SD) age of the patients and duration of SLE was 39.1 (10.0) and 9.9 (6.2) years, respectively. Two (1.2%) patients were classified as mild low weight, 59 (34.7%) as normal weight, 61 (35.9%) as pre-obese, 37 (21.8%) as obese class I, seven (4.1%) as obese class II and four (2.4%) as obese class III. Patients were classified into three groups (normal weight, overweight and obese). Overweight and obesity was significantly associated with older age, worse education level, higher damage index of SLE, increased concentration of complement, higher frequency of hypertension and diabetes mellitus, ovarian insufficiency and lower use of antimalarials. When classified into two groups (normal weight and excess weight) 109 patients presented with excess weight. Patients whose age was older than forty years, who had less than eight years of education, without any job, with damage index higher than one, with hypertension, diabetes mellitus, serum creatinine higherthan or equal to 0,87mg/dL and the triglycerides higher than or equal to 150mg/dL presented with excess weight. Antimalarial and corticosteroids usage was associated with lower frequency of excess weight. In multivariate analysis age, serum creatinine and no used of methotrexate were the variables independently associated with excess weight. 18.2% of patients were classified as physical active, 58.8% moderately active and 22.9% completely sedentary. Conclusions: The frequency of excess weight was high and associated with factors of worse prognosis in SLE. Furthermore, most patients did not have adequate physical activity, which may have contributed to overweight. The current results reinforce the need to encourage weight control in SLE treatment. Prospective studies should assess whether these characteristics will interfere in the evolution or prognosis.